PT-141 (Bremelanotide) is a synthetic peptide acting as an agonist of melanocortin receptors MC3R and MC4R in the central nervous system. Unlike most research peptides that act peripherally, PT-141 crosses the blood-brain barrier and interacts directly with hypothalamic receptors. This complete guide covers its mechanism of action, scientific research data, legal status, and how to source PT-141 10mg in research-grade quality.
What is PT-141 (Bremelanotide)?
PT-141 is a synthetic cyclic heptapeptide and an analogue of α-MSH (alpha-melanocyte-stimulating hormone). Originally developed as a derivative of Melanotan II, it is distinguished by its selective binding to MC3R and MC4R receptors in the hypothalamus, acting centrally through the nervous system rather than peripherally.
Chemical designation: cyclo[Nle⁴-Asp⁵-αMSH(4-10)]. This cyclic structure confers enhanced stability and specific receptor binding in the CNS.
Important: PT-141 sold by Scandinavian Pen Peptides is a research peptide intended exclusively for scientific laboratory purposes. It is not approved for human or veterinary use.
Mechanism of Action
- Melanocortin receptor agonist (MC3R/MC4R) — PT-141 selectively binds to MC3 and MC4 receptors in the hypothalamus and other CNS regions. This central action fundamentally distinguishes it from peripherally acting peptides.
- Dopaminergic activation — Via MC4R activation, PT-141 influences dopaminergic pathways in the mesolimbic system — an intensively studied area of neurophysiology.
- Pigmentation research — As an α-MSH analogue, PT-141 is also studied in melanin and skin pigmentation research, though with weaker effects than Melanotan II.
Scientific Research on PT-141
Melanocortin System
Studies published in the Journal of Sexual Medicine and the Annals of the New York Academy of Sciences have demonstrated that PT-141 specifically binds to MC3R and MC4R expressed in several hypothalamic nuclei involved in the regulation of autonomic functions. [Source: PubMed]
Central Nervous System
Preclinical studies show that MC4R activation influences dopaminergic neurons in the mesolimbic system. These findings are significant for neuroscience research and the understanding of the melanocortin system within the CNS. [Source: PubMed Central]
Comparison with Melanotan II
While Melanotan II binds to all five melanocortin receptors (MC1R–MC5R), PT-141 is more selective, primarily targeting MC3R and MC4R. This selectivity makes PT-141 a more specific research tool for CNS studies compared to the broader action profile of Melanotan II.
PT-141 vs Other Peptides: Research Comparison
| Peptide | Receptor | Site of Action | Available |
|---|---|---|---|
| PT-141 | MC3R/MC4R | CNS (central) | PT-141 10mg → |
| Melanotan II | MC1R–MC5R | Peripheral + CNS | Melanotan II → |
| GHRP-6 | GHS-R1a | Pituitary/Hypothalamus | GHRP-6 → |
| MOTS-c | AMPK | Skeletal muscle / Nucleus | MOTS-c → |
| BPC-157 | Multiple | Peripheral | BPC-157 → |
Legal Status of PT-141
PT-141 (Bremelanotide) is not classified as a controlled substance or narcotic in most countries. It does not hold marketing authorization as a medicinal product and is therefore not available through pharmacies. Its purchase and possession are legal exclusively for scientific research purposes as a chemical reference compound.
Scandinavian Pen Peptides sells PT-141 strictly within this legal framework.
How to Buy PT-141
When sourcing PT-141 for research purposes, the following quality criteria are essential:
- Purity ≥98% — verifiable via a third-party COA
- HPLC analysis — guarantees exact peptide composition
- Batch number — full traceability
- Precise format — accurate dosing for research protocols
- International shipping — fast and secure delivery
Our PT-141 10mg pen format meets all these criteria: purity ≥98%, COA included, fast delivery.
PT-141 10mg — Pre-mixed Pen Format
View Product →Purity ≥98% · COA Included · EU & International Shipping
Why the Pen Format for PT-141?
- Precise dosing — no manual reconstitution required
- Guaranteed sterility — sealed solution, minimized contamination risk
- Optimized stability — buffered formula, storage at 2–8°C
- Full traceability — unique batch number per pen
Other Research Peptides Available
- Melanotan II 10mg — broad-spectrum melanocortin research
- GHRP-6 5mg — GH-releasing peptide
- MOTS-c 10mg — mitochondrial peptide
- BPC-157 5mg — regenerative peptide
- CJC-1295 No DAC 5mg — GHRH analogue
- Ipamorelin 10mg — selective GH secretagogue
FAQ — Frequently Asked Questions about PT-141
What is PT-141 (Bremelanotide)?
PT-141 is a synthetic cyclic heptapeptide and analogue of α-MSH that selectively binds to melanocortin receptors MC3R and MC4R in the CNS. Developed as a derivative of Melanotan II, it is a unique research tool for studying the central melanocortin system.
Is PT-141 a research peptide?
Yes. PT-141 is sold exclusively as a research peptide for scientific laboratory use. It is not approved as a medicinal product and is not intended for human consumption. Scandinavian Pen Peptides sells it strictly within this legal framework.
What is the difference between PT-141 and Melanotan II?
Melanotan II binds to all five melanocortin receptors (MC1R–MC5R) with both peripheral and central effects. PT-141 is more selective, primarily targeting MC3R and MC4R in the CNS — making it a more specific research tool for central nervous system studies.
Can PT-141 be purchased at a pharmacy?
No. PT-141 does not hold marketing authorization as a medicinal product and is not available through pharmacies. It is a research peptide available exclusively from specialized suppliers such as Scandinavian Pen Peptides.
What is the purity of PT-141 from Scandinavian Pen Peptides?
Purity ≥98%, verified by HPLC analysis. A Certificate of Analysis (COA) is included with every order.
What is the difference between PT-141 and GHRP-6?
GHRP-6 is a growth hormone-releasing peptide acting via ghrelin receptors (GHS-R1a) in the pituitary and hypothalamus. PT-141 acts via completely different receptors (MC3R/MC4R) in the CNS. Both peptides have fundamentally different and non-overlapping research profiles.
What is the advantage of the pen format for PT-141?
The pre-mixed pen format ensures precise concentration, eliminates manual reconstitution steps and reduces contamination risk — ideal for reproducible research protocols.
Do you ship PT-141 internationally?
Yes. Scandinavian Pen Peptides ships to the EU, UK, Switzerland, and internationally. Fast and secure delivery with discreet packaging.
Conclusion
PT-141 (Bremelanotide) is a unique research peptide with a central mechanism of action via melanocortin receptors MC3R and MC4R. In pre-mixed pen format with purity ≥98%, it is optimally suited for rigorous laboratory protocols.