HGH Fragment 176-191 is a synthetic peptide fragment corresponding to amino acids 176 to 191 of human growth hormone (HGH). Specifically designed to isolate the lipolytic activity of GH without its systemic growth effects, it is studied as a research tool in the fields of fat metabolism and energy regulation. This complete guide covers its mechanism of action, available scientific data, legal status, and how to source HGH Fragment 176-191 5mg in research-grade quality.
What is HGH Fragment 176-191?
HGH Fragment 176-191 is a synthetic peptide fragment corresponding to amino acids 176 to 191 of human growth hormone (somatotropin). Developed in the 1990s by researchers at Monash University in Australia, it was designed to isolate the lipolytic activity of GH — without the tissue growth and other systemic effects of the full molecule.
Its sequence: Tyr-Leu-Arg-Ile-Val-Gln-Cys-Arg-Ser-Val-Glu-Gly-Ser-Cys-Gly-Phe. This fragment contains the C-terminal region of GH responsible for interaction with adipocytes.
Important: HGH Fragment 176-191 sold by Scandinavian Pen Peptides is a research peptide intended exclusively for scientific laboratory purposes. It is not approved for human or veterinary use.
Lipolytic Mechanism of Action
Fragment 176-191 acts via two primary mechanisms:
- Activation of β-adrenergic adipocyte receptors — The fragment binds to β-3 receptors on adipocytes, stimulating lipolysis (breakdown of triglycerides into free fatty acids). This mechanism is identical to that of the C-terminal region of native GH.
- Inhibition of lipogenesis — Preclinical studies show that the fragment also inhibits the formation of new fat deposits, creating a dual effect on lipid metabolism.
Scientific Research on HGH Fragment 176-191
Lipolysis and Adipocytes
Studies published in Biochemistry and the Journal of Endocrinology demonstrated that Fragment 176-191 stimulates lipolysis in adipocytes in vitro comparably to native GH, while being devoid of hyperglycemic effects. [Source: PubMed]
Metabolic Selectivity
A study by Ng et al. (Monash University) showed that the fragment does not stimulate cell proliferation or water retention — unlike full-length GH. This property is significant for studies on selective lipid metabolism. [Source: PubMed Central]
Comparison with Native GH
In vivo models showed that Fragment 176-191 exhibits approximately 12.5 times greater lipolytic activity in adipocytes than native GH, according to preclinical data. These results remain to be confirmed in further studies.
Fragment 176-191 vs Other Metabolic Peptides
| Peptide | Mechanism | IGF-1 Effect | Available |
|---|---|---|---|
| Fragment 176-191 | β-adrenergic / lipolysis | ❌ No | Frag 176-191 → |
| GHRP-6 | GHS-R1a / ghrelin | ✅ Indirect | GHRP-6 → |
| CJC-1295 | GHRH analogue | ✅ Indirect | CJC-1295 → |
| Retatrutide | GLP-1/GIP/Glucagon | ❌ No | Retatrutide → |
| MOTS-c | AMPK / Mitochondrial | ❌ No | MOTS-c → |
For an overview of all metabolic peptides: Peptides — complete research guide.
Legal Status of HGH Fragment 176-191
HGH Fragment 176-191 is not classified as a controlled substance or narcotic in most countries. It does not hold marketing authorization as a medicinal product and is therefore not available through pharmacies. Its purchase and possession are legal exclusively for scientific research purposes as a chemical reference compound.
Scandinavian Pen Peptides sells HGH Fragment 176-191 strictly within this legal framework.
How to Buy HGH Fragment 176-191
When sourcing HGH Fragment 176-191 for research purposes, the following quality criteria are essential:
- Purity ≥98% — verifiable via a third-party Certificate of Analysis (COA)
- HPLC analysis — guarantees the exact peptide composition
- Batch number — full traceability
- Precise format — accurate dosing for research protocols
- International shipping — fast and secure delivery
Our HGH Fragment 176-191 5mg pen format meets all these criteria: purity ≥98%, COA included, fast and secure delivery.
HGH Fragment 176-191 5mg — Pre-mixed Pen Format
View Product →Purity ≥98% · COA Included · EU & International Shipping
Why the Pen Format for HGH Fragment 176-191?
- Precise dosing — no manual reconstitution required
- Guaranteed sterility — sealed solution, minimized contamination risk
- Optimized stability — buffered formula, storage at 2–8°C
- Full traceability — unique batch number per pen
Other Metabolic Research Peptides Available
- Retatrutide 6mg/12mg — triple agonist GLP-1/GIP/Glucagon
- GHRP-6 5mg — GH-releasing peptide
- CJC-1295 No DAC 5mg — GHRH analogue
- MOTS-c 10mg — mitochondrial peptide
- Ipamorelin 10mg — selective GH secretagogue
- BPC-157 5mg — regenerative peptide
FAQ — Frequently Asked Questions about HGH Fragment 176-191
What is HGH Fragment 176-191?
HGH Fragment 176-191 is a synthetic peptide fragment corresponding to amino acids 176–191 of human growth hormone. Developed at Monash University, it selectively isolates the lipolytic activity of GH without triggering tissue growth effects or IGF-1 interaction.
What is the difference between HGH Fragment 176-191 and full-length growth hormone?
Full-length GH (191 amino acids) stimulates tissue growth via IGF-1, water retention, and lipolysis. Fragment 176-191 isolates only the lipolytic activity via β-adrenergic receptors on adipocytes, without IGF-1 interaction or growth effects — making it a highly specific metabolic research tool.
Is HGH Fragment 176-191 a research peptide?
Yes. HGH Fragment 176-191 is sold exclusively as a research peptide for scientific laboratory use. It is not approved as a medicinal product and is not intended for human consumption. Scandinavian Pen Peptides sells it strictly within this legal framework.
Can HGH Fragment 176-191 be purchased at a pharmacy?
No. It does not hold marketing authorization as a medicinal product and is not available through pharmacies. It is a research peptide available exclusively from specialized suppliers such as Scandinavian Pen Peptides.
What is the purity of HGH Fragment 176-191 from Scandinavian Pen Peptides?
Purity ≥98%, verified by HPLC analysis. A Certificate of Analysis (COA) is included with every order, allowing researchers to independently verify product quality and composition.
What is the difference between HGH Fragment 176-191 and Retatrutide for metabolic research?
Fragment 176-191 acts directly on adipocytes via β-adrenergic receptors, affecting only lipid metabolism. Retatrutide is a triple agonist (GLP-1/GIP/Glucagon) influencing multiple metabolic axes including appetite, blood sugar, and lipolysis. They are complementary tools for metabolic research.
What is the advantage of the pen format for HGH Fragment 176-191?
The pre-mixed pen format ensures precise concentration, eliminates manual reconstitution steps and reduces contamination risk — ideal for reproducible research protocols.
Do you ship HGH Fragment 176-191 internationally?
Yes. Scandinavian Pen Peptides ships to the EU, UK, Switzerland, and internationally. Fast and secure delivery with discreet packaging.
Conclusion
HGH Fragment 176-191 is a unique research tool for the selective study of lipid metabolism. Its specificity for β-adrenergic adipocyte receptors without IGF-1 effects makes it a valuable complement to other GH peptides in research protocols.
- GHRP-6 — GH-releasing peptide guide
- Retatrutide — triple metabolic agonist
- Peptides — complete research guide